Imec begins developing SARS-CoV-2 test to identify positive cases and confirm whether someone is contagious in less than five minutes

The groundbreaking approach will use virus particles in exhaled breath for quick, easy, comfortable, large-scale testing

LEUVEN, Belgium, Oct. 23, 2020 — (PRNewswire) — Imec, a world-leading research and innovation hub in nanoelectronics and digital technologies, announced that it has started developing a groundbreaking SARS-CoV-2 test. Unlike current approaches (using blood, saliva, or a nasopharyngeal swab), the new test will identify SARS-CoV-2 virus particles in a person's exhaled breath. The solution promises the accurate identification of a contagious case in less than five minutes. This will make for faster, easier, more comfortable, and larger-scale testing – an essential requirement for getting a grip on epidemics much sooner while limiting their economic and social impact. Imec is teaming up with the UZ Leuven University Hospital for the solution's clinical validation. By the summer of 2021, imec intends to test a functional prototype at Brussels Airport.

This year, it has become abundantly clear that viruses are capable of striking hard and turning people's lives upside down. In order to minimize the effects of epidemics and pandemics on our health, society, and the economy, governments and experts need to be able to swiftly and accurately assess how a virus is spreading. Today's SARS-CoV-2 diagnostic tools come with quite a few limitations, however.

The most sensitive and reliable tool today is the polymerase chain reaction (PCR) test that aims at detecting the virus's genetic material in a nasopharyngeal specimen. This tool's downside is that trained medical personnel must collect the swab, and the process is described by many as highly uncomfortable. Moreover, the test comes with a processing time (in a clinical lab) of about two days.

Another alternative, the rapid antigen test, is less reliable due to its complexity. Lastly, the serological test (which uses a blood sample) is faster and less expensive than a PCR test but only detects whether someone has developed antibodies after the person has been in contact with the virus.

"While each of these tests can provide clues about a current or past infection, none of them can determine to what extent someone can still pass the virus to others. That is why we have started developing a test that indicates, in less than five minutes, whether someone is carrying the SARS-CoV-2 virus and whether they have a high probability of being contagious. To accomplish this, our solution looks for SARS-CoV-2 virus particles in a person's exhaled breath because research shows that breath particles are the virus's main transmission method," says Peter Peumans, CTO of Health Technologies at imec."Provided positive results in our clinical studies, our tool will make testing for SARS-CoV-2 easier, faster, more comfortable, and possible on a much larger scale. Moreover, we are designing our test to flexibly cope with the rise of other viruses and germs that spread via exhaled particles – such as influenza, RSV, and tuberculosis."

Peter Piot, microbiologist and member of the European Commission advisory panel on COVID-19, confirms this: "It is now clear that the virus is transmitted pre-symptomatically via exhaled particles. SARS-CoV-2 testing via breath sample coupled with an ultrafast molecular analysis would be game-changing since it would allow for the timely detection of individuals who are most likely to transmit the virus. Because a breath sample is much less invasive compared to swabs or saliva, it would also allow for more frequent testing and a faster return to normal."

Imec's solution consists of a sample collector and an analysis unit, both of which are being custom developed by imec researchers. Researchers are focusing much of their attention on the sample collector, which will act as the aerosol (and virus particle) collector and support the solution's high-speed real-time quantitative (RT-q)PCR functionality.

"Merging these tasks using conventional technologies would be extremely hard to do. But thanks to our innovation capability when it comes to using silicon, we have developed a chip that effectively does both. Its silicon microscale PCR cavities make for thousands of impactors that allows us to capture the viral particles, while its powerful RT-qPCR functionality brings down the duration of the PCR effort from 50 to 5 minutes. Importantly as well, the standard silicon technology used to build this chip facilitates mass production at a low cost," explains Peumans.

"Thanks to a grant of 2 million euro provided by the Flemish government, we are off to a flying start," says Luc Van den hove, CEO of imec. "After all, the speed with which we will be able to bring this test to the market will greatly depend on the proper financial support. In anticipation of other investors joining this effort, imec has decided to pre-invest the necessary resources as part of our contribution to the global fight against COVID-19."

"We are happy to be teaming up with imec for this exciting new development," says professor Katrien Lagrou, head of the molecular diagnostic lab of UZ Leuven. "Not only will we provide extensive clinical support to validate the test, we will also support the development using the PCR diagnostic know-how we built up at UZ Leuven for over 20 years." The new test could be used very broadly. "Also, for a first SARS-CoV-2 screening of potentially contagious patients or medical staff at hospitals, such a rapid test using exhaled breath will be very valuable," confirms prof. Lagrou.

Following the development of the underlying technology, experts from the UZ Leuven University Hospital will team up with imec to engage in an extensive clinical study. By the summer of 2021, researchers plan to test a functional prototype at Brussels Airport to ensure that the final solution meets all requirements needed to enable people to travel and meet up again safely and comfortably. "At Brussels Airport, we are convinced that testing is and will be a key element in the recovery of the aviation sector." says Arnaud Feist, CEO at Brussels Airport Company. "Creating a safe environment for our passengers is our top priority and, in this context, it is imperative for us to rely on rapid and reliable testing.   

About imec

Imec is a world-leading research and innovation hub in nanoelectronics and digital technologies. The combination of our widely acclaimed leadership in microchip technology and profound software and ICT expertise is what makes us unique. By leveraging our world-class infrastructure and local and global ecosystem of partners across a multitude of industries, we create groundbreaking innovation in application domains such as healthcare, smart cities and mobility, logistics and manufacturing, energy and education.

As a trusted partner for companies, start-ups and universities we bring together more than 4,000 brilliant minds from almost 100 nationalities. Imec is headquartered in Leuven, Belgium and has distributed R&D groups at a number of Flemish universities, in the Netherlands, Taiwan, USA, and offices in China, India and Japan. In 2019, imec's revenue (P&L) totaled 640 million euro. Further information on imec can be found at www.imec-int.com.

Imec is a registered trademark for the activities of IMEC International (a legal entity set up under Belgian law as a "stichting van openbaar nut"), imec Belgium (IMEC vzw supported by the Government of Flanders), imec the Netherlands (Stichting IMEC Nederland, part of Holst Centre and OnePlanet, supported by the Dutch Government), imec Taiwan (IMEC Taiwan Co.), imec China (IMEC Microelectronics (Shanghai) Co. Ltd.), imec India (Imec India Private Limited) and imec Florida (IMEC USA nanoelectronics design center).

About UZ Leuven

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